Just one point separates these teams but expect Villa to extend their advantage, with Christian Benteke scoring in a 1-0 home victory.
The form guide suggests plenty of goals in this London derby and Hammers striker Andy Carroll can get the first of them in a 2-2 draw.
Back Chelsea to come through a tricky test with flying colours with a 2-0 win, Oscar the stand-out choice in the first-scorer market.
The smart money would be on another draw here and this Tyne-Wear derby could very well be a poor goalless affair.
Things could get a whole lot worse for Liverpool here, with Danny Welbeck a solid pick to score first in 2-0 win for resurgent Arsenal.
Everton need to put a run together to threaten the European places and 2-0 win over QPR will be a start, Kevin Mirallas scoring first.
Swansea play with confidence at the Liberty and that will be enhanced by a 2-1 victory which is kicked off by Wilfried Bony's opener.
This crunch clash comes at a good time for United and Wayne Rooney will start the scoring as they earn bragging rights with a 2-0 win.
Backing Southampton's flop to continue would be a sensible move, with Robin van Persie good value to notch first in 3-1 win on Monday.