Liverpool's 100 per cent run will come to an end, with French striker Olivier Giroud breaking the deadlock in a 3-0 win for Arsenal.
Champions Chelsea will be favourites here but the 0-0 draw is definitely a smart choice if you are looking to make some decent money.
With Southampton in action again on Thursday, be bold and back Watford, with Odion Ighalo the likeliest first scorer in a 2-1 success.
This is going to be nothing other than an away win, so backing Sergio Aguero to score first in a 3-1 success will recoup some cash.
Bournemouth look a good bet to get their maiden win with striker Callum Wilson scoring their first Premier League goal in 2-1 victory.
You have to back Swansea to prevail here and you can boost your winnings by plumping for Andre Ayew to score first in a 3-0 victory.
A score draw looks like a money-spinner here so back Nathan Redmond, in fine form last week, to break the deadlock in a 1-1 scoreline.
Everything here is pointing to a home victory, so tip in-form winger Riyad Mahrez to score the opener in a 2-1 success for the Foxes.
The smart money should go on a draw here and back midfielder Jason Puncheon as first goalscorer for Crystal Palace in a 1-1 stalemate.