Expect Olivier Giroud to end his run of six games without a goal by scoring the opener against Sunderland in a 2-0 win for Arsenal.
Eden Hazard has been quiet in recent weeks but the Belgian is a smart bet to score the only goal as West Brom refuse to lie down.
Back Man City's Sergio Aguero to continue his hot streak in Wales by breaking the deadlock, although the match will end in 1-1 draw.
Alexis Sanchez has scored four of Arsenal's last five goals so back the Chilean to open the scoring in a 1-1 draw at Old Trafford..
This will be tight but back Leicester to snatch the points with a 2-1 win and midfielder Esteban Cambiasso to break the deadlock.
Hull have something to play for and Tom Huddlestone could be a good first-scorer bet against former club Tottenham in a 2-1 away win.
Hedge your bets by backing the draw at Upton Park, with Mark Noble opening the scoring for West Ham in a 1-1 stalemate with Everton.
Danny Ings will open the scoring as Burnley bid farewell to the top flight with a 2-0 win against Mark Hughes' Stoke at Turf Moor.
Graziano Pelle will fire Southampton ahead with his 18th goal of the season, but Aston Villa will fight back to secure a 1-1 draw.