Everton have played out two successive goalless draws away from home at Spurs and Swansea and another stalemate looks on the cards.
Both teams will see this as a fixture they can win but will have to settle for a point each in a 1-1 draw despite Troy Deeney's opener.
West Ham have scored 10 goals in their last four league matches and Diafra Sakho will extend that form by scoring first in a 3-1 win.
City have proved they are beatable but are the team to catch and Sergio Aguero can net the only goal in another low-scoring Spurs game.
Stoke have played better than their results so far suggest and Bojan Krkic can repeat last week's opening goal to inspire a 2-1 win.
Southampton must improve defensively but Graziano Pelle has started the season well so back him to add to his tally in a 2-1 victory.
Chelsea have lost on their last three visits but Newcastle have been woeful and Pedro's goal will help condemn them to a 2-0 defeat.
United are yet to really dominate a match but have far too much quality for Sunderland and Memphis Depay can score first in a 2-0 win.
The home team has not won a league meeting between these teams since May 2011 but Philippe Coutinho can help Liverpool to a 2-0 win.