Manchester City should have enough to see off Liverpool’s challenge and midfielder Yaya Toure is a good bet to fire them to a 1-0 win.
Louis van Gaal's sticky start will continue as Adam Johnson picks up where he left off, scoring first for the Black Cats in a 1-1 draw.
Erik Lamela will grab his first goal for Spurs in resounding 3-0 win over QPR as Harry Redknapp’s return to White Hart Lane turns sour.
With Europa League to contend with Hull's attention will be elsewhere, allowing Stoke to claim 3-1 win, Marko Arnautovic scoring first.
Expect Swansea to emerge victorious in this battle of young English managers against Burnley, Gylfi Sigurdsson inspiring a 2-1 win.
Expect Graziano Pelle, prolific in Eredivisie, scoring 50 times in 57 appearances, to get off the mark here in 2-0 win for Southampton.
Back this to be another 2-2 draw for Everton, with Belgian duo Kevin Mirallas and Romelu Lukaku grabbing a goal each against Arsenal.
With a squad galvanised by adversity, Palace will claim a 2-0 win over West Ham, with Jason Puncheon looking good bet to open scoring.
Leicester face a baptism of fire and it should be a comfortable home win for Chelsea, with Diego Costa opening scoring in 3-0 success.