Saints have struggled against their expected top-four rivals which suggests Chelsea can edge this 1-0 thanks to a Diego Costa winner.
QPR have scored at least two goals in each of their last seven home games and that can continue as Charlie Austin nets in a 3-1 win.
Both teams will be desperate to end their losing runs and Newcastle start slowly so expect Romelu Lukaku to score first in a 1-1 draw.
There is nothing to suggest Burnley can end the run of City, who should be comfortable 3-0 winners after David Silva nets the opener.
Hull should have extra confidence after ending a 10-match winless run and Nikica Jelavic can set them on their way to a 2-0 victory.
Just one point separates these teams but expect Villa to extend their advantage, with Christian Benteke scoring in a 1-0 home victory.
The form guide suggests plenty of goals in this London derby and Hammers striker Andy Carroll can get the first of them in a 2-2 draw.
Back Chelsea to come through a tricky test with flying colours with a 2-0 win, Oscar the stand-out choice in the first-scorer market.
The smart money would be on another draw here and this Tyne-Wear derby could very well be a poor goalless affair.