Everton romped to a 3-1 win at Burnley in their last away game and expect the same result here, with Samuel Eto'o breaking deadlock.
In-form Diafra Sakho, likely to return to action after injury, looks a smart bet to score first in a comfortable 2-0 win for West Ham.
Southampton are expected to keep the pressure on leaders Chelsea with a 3-0 victory, the prolific Graziano Pelle opening the scoring.
Argentinian striker Sergio Aguero looks good value to continue his red-hot streak with the only goal for the second successive weekend.
Manchester United have fresh problems in defence but they will have enough to see off Palace in a 3-0 win, Wayne Rooney scoring first.
This will be a close one but back unbeaten Chelsea to claim a 2-1 success against Liverpool at Anfield and Oscar to grab opening goal.
If recent form is anything to go by, a 0-0 draw is a real possibility at Turf Moor, with Burnley yet to win and Hull winless in three.
Sunderland need a resurgence but won't get it at Palace as Neil Warnock's men will triumph 2-0, Mile Jedinak grabbing the opening goal.
Expect the blue half of Manchester to be smiling as City return to winning ways, Sergio Aguero scoring first against United in 3-1 win.