Demba Ba is backed to add to his tally of six goals by opening the scoring for Newcastle, although Man United may rally for a 1-1 draw.
Expect Stoke to grind out a 0-0 draw against Liverpool, but back striker Luis Suarez to open the scoring if there are any goals..
Back Fulham to earn a 2-2 draw, but hedge those bets by having in-form Southampton striker Rickie Lambert to net first in a 2-2 draw..
Everton have been impressive this season and they will prevail 2-1, with Nikica Jelavic given the nod to get on the scoresheet first.
Arsenal have won on four of their last five visits to Upton Park and they will continue that trend, Gervinho with first in a 2-1 win.
West Brom are an easy pick to secure a fourth straight home win in the Premier League, with Shane Long netting first in a 2-0 triumph.
Swansea are expected to prove a cut above here, with 3-1 the chosen scoreline and striker Danny Graham a fair bet to grab the opener.
Mario Balotelli may be worth backing to build on penalty equaliser against Dortmund in midweek by netting first in 2-0 win for City.
Chelsea won 3-1 in this fixture last term and a repeat of that scoreline could well be on the cards, with Frank Lampard netting first.