With Steven Pienaar and Marouane Fellaini banned, take a chance on a draw but hedge bets by taking Leon Osman if there are any goals.
Wigan have the upper hand over Newcastle, where they won last term's corresponding game 4-0, so take Arouna Kone to inspire a 2-1 win.
Spurs are hard to oppose against Fulham and can triumph 2-0, while striker Jermain Defoe is due a goal after a barren run this year.
There is every chance of Sunderland and Norwich sharing the spoils, with Steven Fletcher favourite to score if there are any goals.
Chelsea are backed to prevail 3-1 here against London rivals West Ham at the Bridge, with Eden Hazard getting the nod to net first.
The Gunners may just be the hungrier team against Swansea this time and Olivier Giroud can strike in a 2-1 away victory at the Liberty.
Let's hope Stokecan put their recent problems behind them against West Brom, with Peter Crouch picked to strike in a 2-1 success..
Liverpool can continue their hot streak by beating Southampton, with striker Luis Suarez taken to strike first in a 2-1 away victory.
Manchester United have looked in a clinical mood of late and Robin van Persie can fire them to a 3-0 victory over lowly Reading here..