Stoke can earn a share of the spoils with a 1-1 draw, although Pavel Pogrebnyak is backed to open the scoring for new-boys Reading.
Go for a fired-up QPR to prevail 2-1 with Djibril Cisse taken to break the deadlock after netting six times in eight games last term.
Percentage pick is to side with Fulham, for whom Mladen Petric can prove a shrewd signing and is fancied to strike first in a 2-1 win.
Take Arsenal to begin the post-Robin van Persie era with 2-0 win, with Lukas Podolski striking first after looking sharp in pre-season.
With nothing at stake but pride here the percentage pick is to go for a home win, with Victor Moses netting first in a 2-0 success.
Arsenal are fancied to hold nerve and clinch a place in next season’s Champions League with a 2-1 win, Robin van Persie with opener.
Spurs have far more at stake and it will be a surprise if they don’t come out on top, with Emmanuel Adebayor scoring first in 3-1 win.
Liverpool’s desire to finish above arch-rivals Everton is the incentive which will see them win 2-1, with Luis Suarez opening scoring.
The Red Devils have not been firing on all cylinders for some time but they should see off Sunderland, Nani netting first in a 2-1 win.