Man United will have enough to grind out a 2-0 home victory over Norwich, with Javier Hernandez tipped to net first at Old Trafford.
It will be a surprise if Everton don't brush aside Reading, with a 3-1 home win on the cards and Leon Osman looking to strike first.
Chelsea have to get the vote here against West Brom, with Juan Mata tipped to open the floodgates in a 3-0 triumph at Stamford Bridge.
Man City look the percentage pick, while Carlos Tevez has a great record against Chelsea and can hit the target in a 2-1 home win.
A 1-1 derby stalemate could be on the cards between West Ham and Tottenham, with Kevin Nolan tipped to enjoy more success up front.
Side with Wigan to secure a crucial 2-1 triumph at against Reading and Arouna Kone can build on his good form with the first goal.
Manchester United can coast to a 3-1 victory over struggling QPR, with Robin van Persie is an obvious choice to open the scoring..
Marouane Fellaini is the best bet to break the deadlock for Everton if there are any goals in a low-scoring draw at Norwich tomorrow.
Striker Dimitar Berbatov gets the nod to net first in a repeat of last term's 2-1 triumph for Fulham against Stoke at Craven Cottage.