This is a tough one to call but the slight preference goes to Liverpool, with Luis Suarez fancied to open the scoring in a 2-1 win.
Chelsea are percentage pick to prevail 2-1, with Oscar just preferred to Eden Hazard for first score bets after impressing in midweek.
Back champions Manchester City to secure a clinical 2-0 success over Swansea in this one, with Carlos Tevez tipped to strike first.
Fulham just about get the nod to prevail 2-1 at Reading, with striker Dimitar Berbatov taken to break the deadlock in the first half..
Expect Villa and Norwich to share a tight 1-1 stalemate, while promising Belgium striker Christian Benteke can net first for Villa..
Stoke look a percentage pick to edge out a Sunderland side struggling for goals, with Peter Crouch tipped to net first in a 2-0 win..
Wigan should come out on top 2-1 against West Ham, with shrewd summer signing Arouna Kone a leading contender to open the scoring.
The most sensible bet is to for Arsene Wenger's Arsenal to just shade it 2-1against QPR and try Santi Cazorla for first scorer bets..
Everton will prove too strong for a QPR side short on confidence, with Nikica Jelavic getting the nod to open the scoring in a 2-1 win.