Arsenal have won on four of their last five visits to Upton Park and they will continue that trend, Gervinho with first in a 2-1 win.
West Brom are an easy pick to secure a fourth straight home win in the Premier League, with Shane Long netting first in a 2-0 triumph.
Swansea are expected to prove a cut above here, with 3-1 the chosen scoreline and striker Danny Graham a fair bet to grab the opener.
Mario Balotelli may be worth backing to build on penalty equaliser against Dortmund in midweek by netting first in 2-0 win for City.
Chelsea won 3-1 in this fixture last term and a repeat of that scoreline could well be on the cards, with Frank Lampard netting first.
A hard-fought draw looks on the cards here, with Bobby Zamora an obvious pick to net for QPR against West Ham if there are any goals.
Expect history to repeat itself with sixth 2-1 scoreline in seven meetings with Villa coming out on top and Darren Bent scoring first.
Having beaten Spurs in their last six league meetings at Old Trafford by an aggregate score of 15-3, let's go for 3-1 Man Utd victory.
Home advantage makes Sunderland an easy pick to prevail 2-1 over Wigan, with striker Steven Fletcher an obvious choice to score first.