Back Sir Alex Ferguson's side to prevail 2-1 here, with the in-form Robin van Persie once more an obvious pick to open the scoring.
It would be no surprise to see another close encounter but Arsenal just fancied to edge a 2-1 victory, with Theo Walcott netting first.
On-loan Chelsea striker Romelu Lukaku will notch his fourth goal of season to help West Brom to 2-0 victory against struggling Saints.
Both teams desperately need their first league win but expect another draw, with Pavel Pogrebnyak scoring first in a 1-1 stalemate.
Expect Liverpool to continue their league improvement with a convincing 3-0 victory, with Luis Suarez the top tip to open the scoring.
Expect goals at both ends in an entertaining clash, with Man City’s Carlos Tevez to strike first in a 3-1 away victory at West Ham.
Spurs will ease to a comfortable 3-0 victory against Wigan having been sent on their way by Gareth Bale’s opener at White Hart Lane.
Back Oscar to net the opener for Chelsea as they run out comfortable 2-1 victors at the Liberty Stadium against inconsistent Swansea.
Expect another stalemate here, with in-form Villa forward Christian Benteke opening the scoring in a 1-1 draw at the Stadium of Light.